Saturday, February 29, 2020

Airborne infectious disease

Airborne infectious disease Tuberculosis (TB) is an airborne infectious disease which is caused by bacteria belonging to Mycobacterium tuberculosis complex1. There are approximately one third of the world’s population are infected with tuberculosis where nine millions of new cases reported annually2. Although tuberculosis is essentially curable and preventable, it continues to cause millions of deaths every year2. When infected individual coughs, sneezes or spits, M. tuberculosis is propelled into the air and infected those who breathed in the bacteria that existed in droplets of saliva3. Primarily, tuberculosis will affect the lungs, known as pulmonary tuberculosis3. It will also affect other parts of body, for instance lymph nodes, bones, brain and kidneys3. Once a person is infected with tuberculosis, there are basically three possible ways may occur. Firstly, the immune system plays a vital role and strong enough to kill the bacteria3. Secondly, immune system is not strong enough to fight off the ba cteria but is able to build a defensive barrier against the bacteria3. Individuals who are latently infected with M. tuberculosis show asymptomatic where these bacteria lie dormant in the lungs and able to reactivate after years1. The disease is often reactivated in those who are immunocompromised or generally weakened. Lastly, the immune system fails to kill bacteria causing the bacteria to grow and spread towards other parts of body which is called active tuberculosis3. In the fight of tuberculosis, World Health Organisation (WHO) recommends universal Bacille Calmette-Guà ©rin (BCG) vaccination in the countries with high TB burdens4. BCG vaccine contains weakened form of M. tuberculosiswhich will induce antibodies to fight against this type of bacteria. The efficacy of BCG vaccination can be ranging from 0% to 84%5. This may be due to the frequency of TB exposure and quality of vaccine used, leading to arguments on BCG vaccination efficacies4. One of the greatest arguments is th at BCG vaccination causing positive reactions to tuberculin skin testing and hence interfere with the diagnosis of latent TB4. Existence of evidences showing the rates of efficacy also depends on geographical location, age at vaccination and form of TB further complicate the situation. Currently, TB chemotherapy is made up of a cocktail of first-line drugs isoniazid (INH), rifampicin (RIF), pyrazinamide (PZA) and ethambutol (EMB) 6. If the treatment fails due to bacterial drug resistance, or patient unable to tolerate, second-line drugs for instance para-aminosalicylate (PAS), fluoroquinolones, ethionamide and cycloserine are introduced6. These are considered as second line drugs generally either less potent with larger doses or more toxic with serious side effects6. Tuberculosis is presently treated in two phases, namely initial phase and continuous phase7. In initial phase, the patient will be treated with concurrent use of four first line drugs, with the aim to eradicate or contr ol bacteria population to replicate in rapid motion and also avoid the emergence of bacteria resistance7. The treatment choices available for initial treatment include isoniazid, rifampicin, pyrazinamide and ethambutol7. Streptomycin is used rarely but can be used in patients who infected with bacteria that are resistant to isoniazid before the therapy is commenced7. The duration for initial phase is 2 months whereas the continuous phase takes 4 months7. During the four months of continuous phase, patients are treated with isoniazid and rifampicin at same doses7. Most of the TB treatment is supervised where drug administration needs to be fully supervised by healthcare professions since lengthy duration of treatment causing incompliance in patients7. These patients who are unlikely to be compliance will be given the drugs three times a week until the course is completed while patients who able to comply with the treatment will not be supervised7.

Thursday, February 13, 2020

Fungi as a source of food Essay Example | Topics and Well Written Essays - 750 words

Fungi as a source of food - Essay Example There is vitamin d2 production when ergosterols in mushrooms are exposed to ultraviolet light. Fungi have certain interesting twists especially when one zeros down to the mushrooms. In the ancient Egypt for example, mushrooms were exclusively believed to be foods for the royalties. The unique flavors intrigued the powerful pharaohs to the extent of declaring them illegal for the commoners to consume. In china, Greece, Mexico, Russia and Latin America, the practice of mushroom rituals took place. They believed that mushrooms possessed properties capable of producing super human strengths. They also believed that mushrooms could help recover lost objects, and take the human soul to the presence of the gods (Phillips and Reid 62). Edible fungi like mushroom have been in consumption since the 18th century. France prides early leadership in the farming of mushrooms with certain accounts stating that Louis XIV being the first mushroom grower. Mushrooms were grown near Paris in special caves set aside for this activity. Mushroom farming later spread to England since the farmers there found it very easy to grow. It demanded low investments, less labor and space. Mushroom farming found its way to the United States in the 19th century though the growers there largely depended on the spawn they imported from England (Phillips and Reid 32). A book was published in 1891 shedding a lot of light on mushroom growing. Immediately after, the department of agriculture in the U.S allocated some money in research and produced a pure-culture virgin spawn cutting their dependency on imported spawn. The growth of mushroom production has since then achieved great development in the U.S. Recent research by scientists on hallucinogen psilocybin, which is an active ingredient in mushrooms, shows that one dose causes serious positive personality change in their patients. The changes were

Saturday, February 1, 2020

Legal Department Essay Example | Topics and Well Written Essays - 1000 words

Legal Department - Essay Example As Adoranti (2006) explains, business to business and commercial contracts explicitly define the obligations of sellers and buyers. This includes the specifications of the contacted for products/services, their quality and time/place of delivery. The violation of contractual obligations, on either side, can be cause for the invalidation of the contract and grounds for the payment of financial penalties (Adoranti, 2006). As our organization's legal councilor emphasized, the binding form of contracts implies that it is incumbent upon the organization to ensure that a contract works in its favor and not against it. Hence, within the context of our organization, the policy is that no sales contract is signed prior to the formulation of an inter-departmental business plan which details how the organization will fulfill the contract and whether, indeed, it can. Only following a thorough review of this plan does the legal department authorize the signature of the contract. The regulations which the legal department has imposed upon contractual commitments are an outcome of prior negative experiences. Two years ago an overenthusiastic sales department committed the company to the supply of more than it could produce within a specified time period. As the Sales Director had the authority to conclude contracts, the outcome was the overextension of corporate resources in a bid to satisfy its contractual obligations and, ultimately, a failure to meet the time of delivery, resulting in the imposition of fines upon the company. This incident, as the corporate legal councilor informed me, instigated a revision of corporate policy, whereby contracts could only be entered into following inter-departmental meetings and the formulation of business plans which outline strategies for the fulfillment of contractual obligations. Contracts, however, do not represent the extent of the legal department's involvement in corporate and business processes and relations. Indeed, one of the department's primary concerns is employee relations, the implementation of corporate policy and the assurance of adherence. Insofar as the aforementioned is concerned, Poole (2004) identifies it as one of the more important of any corporate legal department's responsibilities, comparable to the implementation of law and order. As such, the legal department governs/supervises employee relations and ensures adherence to a specific code of conduct. This code of conduct extends to company-related behavior following the termination of the employee-employer relation. For example, in the event of an employee's dismissal for non performance of job related responsibilities, he/she is, as per the employment contract signed, warned against both defaming the company and exposing company business secrets. This, as the legal councilor advised m e, was standard practice in most organizations but, without doubt, one of the more important of the legal department's responsibilities as it involved the safeguarding of the company from disgruntled former employees. The protection of the company against defamation, not just by former employees but by competitors and the media consumes much of the legal depa